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. 2015 Sep 22;8(4):177–183. doi: 10.1177/1753495X15598917

Table 2.

Summary of apoplexy cases during pregnancy and the peripartum period from the literature review and our academic centre.

Age (years) Prior lesion WG at presentation Symptoms
 Treatment
Headaches Nausea Visual disturbances Hormonal replacement Bromocriptine and cabergoline Surgery
Kannuki et al.7 28 PRL 6 + + ? ? ?
Ohtsubo et al.8 29 (multi) AD 24 + + + +
Kita et al.9 26 (G1) – 26 + + +
Atmaca et al10 33 MAD 37 + + + +
Luliano et al.11 28 MAD 29 + + + + +
Gheorghiu et al.12 33 AD 22 + + +
Perotti et al.13 29 – 2 h PP + + + + +
Schrupp et al.14 31 (G1) – 1 wk PP + + −
Jassal et al.15 32 (multi) – 4 days PP + + +
Freeman et al.16 22 MAD 32 + + +
Tonda et al.17 22 – 32 + + +
Krull et al.18 28 (G1) – 7 + +
O'Donovan et al.19 37 (multi) MPRL 8 + + + +
Murao et al.20 35 – 39 + +
Nagulesparan et al. 21 34 – 31 + + +
Gondim et al.22 29 MPRL 30 + + + + +
Zammit-Mangion et al.23 28 – 16 + + +
Zammit-Mangion et al.23 31 - 18 + + +
Onesti et al.24 28 – ? + + +
Hervet et al.25 26 – 24 + + +
Parihar et al.26 22 MPRL 20 + + +
Witek et al.27 25 (G1) MPRL 14 + + + +
Scherrer et al.28 ? MAD 16 + + +
Scherrer et al.28 ? mAD 28 + + +
Lunardi et al.29 21 (multi) – 24 + + +
Fujimaki et al.30 23 (G1) – 24 + +
Ginath et al.31 31 (G1) PRL 39 + + +
Heide et al.32 26 (multi) – 23 + + +
Janssen et al.33 27 (G1) – 10 + + + +
Bamfo et al.34 31 (G1) – 10 + + +
Lee et al.35 26 (G1) – 24 + + + +
Lamberts et al.36 30 (G1) PRL 23 + + + +
Rosen et al.37 32 – 22 + + +
Patients from the CHUM
Case 1 33 (G6) – 39 + + − − – −
Case 2 30 (G1) MPRL 20 − − − − + −
Case 3 37 (G1) mPRL 16 + + + − + −
Case 4 40 (G4) – 6 h PP + − − + − −
All 37 patients 29a 9 MAD (5 PRL) 5 mAD (4 MPRL) 24 (4 PP) 35/37 (95%) 13/37 (35%) 22/37 (59%) 21/36 (58)% 11/36 (31%) 15/36 (42%)
a

Median age.

Note: The treatment used in Kannuki's case6 was not specified, but we found the treatment in Ohtshubo's case7 in an English abstract. In total, treatments were specified for 36 patients. AD: adenoma non-specified; MAD: macroadenoma non-specified; mAD: microadenoma non-specified; PRL: prolactinoma; MPRL: macroprolactinoma; mPRL: microprolactinoma; GA: Gestational age; PP: postpartum; CHUM: Centre Hospitalier de l'Université de Montréal; WG: weeks of gestation.