Table 2.

Case repots of methyldopa associated liver failure.

Case report	Maternal age (years)	GA at which methyldopa initiated (weeks)	GA at symptom onset (weeks)	Symptoms	Outcome
Picaud et al.5 *Abstract only	22	33	3rd trimester	Initial symptoms of nausea, vomiting, and increased temperature; associated with febrile jaundice and coagulopathy in the third stage of labor. Patient passed away 3 days after delivery due to hematemesis, renal failure, and hepatic encephalopathy.	Maternal death 3 days after delivery
Smith and Piercy6	30	10	13	Jaundice, abdominal pain, nausea	Methyldopa discontinued at 14 weeks and re-introduced at 36 weeks’ gestation; C-section for family planning
Thomas and Cardwell7	37	6	15	Jaundice, dark urine	Complete resolution of symptoms at 21 weeks with discontinuation of medication
Phadis et al.12	40	6	8	Jaundice, dark urine, myalgia, fatigue, fever	Switched to labetalol and liver function gradually improved between 10 and24 weeks
Ali et al.8	33	6	12	Jaundice, dark urine	Resolved 2 weeks later with a course of prednisone
Ozsvar et al.9	35	21	23	Transaminitis	Switched to nifedipine; no information on outcome
Slim et al.10	34	13	17	Jaundice, pruritus, dark urine, pale stool	Liver function test results returned to normal levels within 5 weeks of discontinuation

GA: gestational age.