Table 3.
Multivariate analysis of clinical variables for patients with GIST
| Clinicopathological parameters | CXCL16
|
CXCR6
|
sCXCL16
|
Tregs
|
||||
|---|---|---|---|---|---|---|---|---|
| Relative risk (95% CI) | P-value | Relative risk (95% CI) | P-value | Relative risk (95% CI) | P-value | Relative risk (95% CI) | P-value | |
| Sex (male) | 0.60 (0.16–2.24) | 0.075 | 0.61 (0.17–2.22) | 0.223 | 0.81 (0.23–2.92) | 0.335 | 0.80 (0.22–2.90) | 0.265 |
| Age (>55 years) | 2.31 (0.63–8.51) | 0.067 | 1.15 (0.34–3.89) | 0.325 | 1.64 (0.49–5.50) | 0.421 | 1.12 (0.34–3.73) | 0.215 |
| Tumor size (≥10 cm) | 0.63 (0.18–2.27) | 0.124 | 3.79 (0.97–14.78) | 0.053 | 0.44 (0.13–1.52) | 0.246 | 0.11 (0.03–0.47) | 0.025 |
| Tumor number | 1.09 (0.23–5.16) | 0.225 | 0.27 (0.06–1.29) | 0.084 | 0.63 (0.14–2.77) | 0.365 | 0.18 (0.03–0.98) | 0.042 |
| Mitotic index | 0.29 (0.08–1.10) | 0.062 | 0.49 (0.14–1.74) | 0.135 | 0.17 (0.04–0.69) | 0.034 | 0.66 (0.19–2.32) | 0.367 |
| Tumor necrosis | 0.77 (0.21–2.88) | 0.321 | 2.57 (0.72–9.17) | 0.086 | 1.25 (0.36–4.32) | 0.402 | 0.36 (0.10–1.34) | 0.435 |
| Tumor bleeding | 0.58 (0.16–2.06) | 0.164 | 9.00 (2.19–36.9) | 0.016 | 1.59 (0.48–5.31) | 0.207 | 0.51 (0.15–1.73) | 0.258 |
| Surrounding tissue invasion | 5.25 (1.35–20.4) | 0.024 | 5.78 (1.58–21.1) | 0.025 | 4.38 (1.21–15.8) | 0.033 | 0.63 (0.19–2.10) | 0.267 |
Note: Data in bold indicates statistical significance.
Abbreviations: GIST, gastrointestinal stromal tumors; CI, confidence interval; sCXCL16, serum CXCL16.