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. 2016 Jun 28;11:3009–3022. doi: 10.2147/IJN.S107442

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© 2016 Harigae et al. This work is published and licensed by Dove Medical Press Limited

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Representative chromatograms of curcuminoids.

Notes: Representative chromatograms of identified curcuminoids (except CUR and CURG) in rat plasma at 1.5 hours following oral administration of CUR (100 mg/kg) or CUR-NP (at a dose equivalent to 100 mg CUR/kg). Each rat plasma sample (100 μL) was extracted in 1 mL of methanol and 10 μL of it was analyzed by HPLC-MS/MS with MRM. The left chromatograms are from the CUR-administrated group and the right chromatograms are from the CUR-NP-administrated group. (A, B) CURS; (C, D) CURGS; (E, F) DHCG; (G, H) THCG; (I, J) HHCG; (K, L) DHCS; (M, N) THCS; (O, P) HHCS.

Abbreviations: CUR, curcumin; CURG, curcumin glucuronide; CUR-NP, curcumin nanoparticles; cps, centipoise; CURS, curcumin sulfate; CURGS, curcumin glucuronide sulfate; DHCG, dihydrocurcumin glucuronide; THCG, tetrahydrocurcumin glucuronide; HHCG, hexahydrocurcumin glucuronide, DHCS, dihydrocurcumin sulfate; THCS, tetrahydrocurcumin sulfate; HHCS, hexahydrocurcumin sulfate; HPLC-MS/MS, high-performance liquid chromatography-tandem mass spectrometry; MRM, multiple-reaction monitoring.