Table 2.
Case reports of successful pregnancies in mothers with ALGS
| Study | LT before pregnancy | Maternal age (years) | Prenatal counseling | Chorionic villous sampling | Delivery (gestational week) | Delivery (technique) | ALGS in the newborn | Newborn outcome at 1 year |
|---|---|---|---|---|---|---|---|---|
| Witt et al44 | No | NA | Yes | Yes | NA | NA | No | NA |
| Albayram et al45 | No | 21 | No | No | 35 | Spontaneous vaginal delivery | Yes | Death at 3 months |
| Herr et al46 | No | NA | NA | NA | 36 | Cesarean section | Yes | NA |
| Rahmoune et al47 | No | 34 | Yes | No | 34 | Cesarean section | Yes | NA |
| Maisonneuve et al48 | Yes | 22 | No | Yes | 37 | Elective forceps delivery | Yes | NA |
| Jung et al49 (case series of four pregnancies) | One out of four moms | NA | Yes | Yes | NA | NA | One out of four newborns |
Abbreviations: ALGS, Alagille syndrome; NA, not applicable; LT, liver transplantation.