Table 3.
Significantly different metabolites among LC and PD
| Parameter | LC | PD | FC | P Value |
|---|---|---|---|---|
| BB307889 | 450 ± 51 | 2,082 ± 1163 | 2.210 | ≤0.01 |
| BB225396 | 318 ± 34 | 1,455 ± 338 | 2.194 | ≤0.05 |
| β-Sitosterol | 958 ± 68 | 2,848 ± 238 | 1.572 | ≤0.01 |
| 3-Phenyl-3-hydroxypropanoic acid | 279 ± 21 | 764 ± 74 | 1.453 | ≤0.01 |
| 2,3-Dihydroxybutanoic acid | 572 ± 91 | 1,516 ± 177 | 1.406 | ≤0.01 |
| 4-Hydroxyproline | 3,397 ± 254 | 8,804 ± 1,075 | 1.374 | ≤0.05 |
| Xylitol | 2,679 ± 241 | 5,953 ± 688 | 1.152 | ≤0.05 |
| BB199250 | 1,502 ± 161 | 3,258 ± 238 | 1.117 | ≤0.01 |
| 2-Deoxyerythritol | 2,202 ± 172 | 4,113 ± 193 | 0.901 | ≤0.01 |
| BB280602 | 179 ± 19 | 319 ± 26 | 0.834 | ≤0.05 |
| Citric acid | 51,760 ± 4,875 | 82,715 ± 3,460 | 0.676 | ≤0.05 |
| BB199794 | 9,865 ± 920 | 15,443 ± 889 | 0.647 | ≤0.05 |
| BB270003 | 1,123 ± 137 | 1,753 ± 127 | 0.642 | ≤0.05 |
| BB232087 | 53,012 ± 4,418 | 82,559 ± 3,476 | 0.639 | ≤0.05 |
| BB310006 | 374 ± 26 | 579 ± 48 | 0.631 | ≤0.05 |
| BB433267 | 20,248 ± 1,970 | 30,905 ± 1,611 | 0.610 | ≤0.05 |
| BB404568 | 925 ± 70 | 1,355 ± 79 | 0.551 | ≤0.05 |
| Isothreonic acid | 700 ± 64 | 1,012 ± 49 | 0.532 | ≤0.05 |
| Indole-3-acetate | 295 ± 12 | 426 ± 28 | 0.530 | ≤0.01 |
| N-methylalanine | 8,660 ± 451 | 12,442 ± 824 | 0.523 | ≤0.05 |
| BB199777 | 50,042 ± 3,656 | 71,849 ± 3,438 | 0.522 | ≤0.05 |
| BB318770 | 49,822 ± 3,812 | 71,548 ± 3,421 | 0.522 | ≤0.05 |
| Threonine | 62,697 ± 2,290 | 85,811 ± 2,652 | 0.453 | ≤0.01 |
| Phosphoric acid | 152,729 ± 6,372 | 121,622 ± 5,615 | −0.329 | ≤0.05 |
| Urea | 495,391 ± 4,4187 | 286,409 ± 16,521 | −0.790 | ≤0.05 |
| α-Ketoglutaric acid | 3,766 ± 391 | 2,059 ± 175 | −0.871 | ≤0.05 |
| BB208647 | 2,964 ± 260 | 1,384 ± 91 | −1.099 | ≤0.01 |
| Monopalmitin-1-glyceride | 371 ± 26 | 172 ± 24 | −1.109 | ≤0.05 |
| 1, 5-anhydroglucitol | 23,197 ± 1,682 | 10,561 ± 2,033 | −1.135 | ≤0.05 |
| Threonic acid | 4,907 ± 664 | 2,207 ± 333 | −1.153 | ≤0.05 |
| 1-Monostearin | 1,993 ± 364 | 142 ± 10 | −3.811 | ≤0.05 |
Values in LC and PD columns are means ± SE.
LC, lean Sprague-Dawley controls (n = 7); PD, prediabetic UCD-T2DM rats (n = 8); FC, log2 fold change of PD relative to LC means; BB, BinBase. Unidentified metabolites indicated with their BB nomenclature. Units are quantifier ion peak heights from time-of-flight/gas chromatography/mass spectrometry. Mann-Whitney U-tests were used to compare LC and PD groups. False discovery rate-adjusted P values (Benjamini and Hochberg) are given.