Fig. 8.

Lipid and adipokine profiles of Ctrp5-null mice fed a high-fat diet. A: representative histological sections of liver from WT and KO mice stained with hematoxylin and eosin. B and C: liver triglyceride and cholesterol levels of WT and KO mice. D–G: serum concentrations of triglycerides, cholesterol, and nonesterified free fatty acids (NEFA) and β-hydroxybutyrate (ketone) in WT and KO mice. H: skeletal muscle triglyceride levels of WT and KO mice. I: quantitative PCR analysis of genes involved in de novo lipid synthesis (Scd1, Fasn, Srebp1c, and Acc1) and fat oxidation (Lcad and Mcad) in WT and KO mouse liver. J: expression of genes (Gpat, Agpat, and Dgat) involved in triglyceride synthesis in WT and KO mouse liver. All expression levels were normalized to 18s rRNA. WT, n = 8; KO, n = 7. *P < 0.05.