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. 2016 May 3;310(11):E1027–E1035. doi: 10.1152/ajpendo.00040.2016

Fig. 3.

Fig. 3.

SPARC deletion inhibited collagen deposition in the aged heart. A: representative images of picosirius red (PSR)-stained sections from the LVs of young, middle-aged, and old WT and Null mice and %PSR-positive area per total area showing age-dependent increase in collagens in WT mice. Scales, 50 μm. #P < 0.05 among ages in each genotype; *P < 0.05 vs. age-matched WT. B: cardiac expression of SPARC protein (%SPARC-positive area/total area) and collagen content increased with age. Pearson correlation analysis revealed significant correlation between SPARC expression and collagen deposition in the aging myocardium.