Figure 1.

Effect of genotype of BERK (three left bars in each panel) and Townes mice (three right bars in each panel) on current vocalization threshold to 2000 Hz (panel a), 250 Hz (panel b), and 5 Hz (panel c) and thermosensory response to hot (panel d) and cold plate (panel e) controlling for sex and age. C57BL/6 mice were used as control BERK animals. Townes controls were nonsickling littermates of heterozygous and homozygous Townes mice that expressed normal human hemoglobin. P values reflect comparison of groups indicated by horizontal bars