Fig. 5.

Rab25 knockdown inhibits pressure- and depolarization-induced vasoconstriction in cerebral arteries. A: representative traces showing vasoconstriction to increasing extracellular K⁺ in scrm control (black) and Rab25 siRNA arteries (red). B: mean data illustrating depolarization-induced vasoconstriction in scrm control and RAB25 siRNA arteries (n = 12–16 for scrm; n = 7–8 for Rab25 siRNA). C: representative traces of pressure (60 mmHg)-induced vasoconstriction, illustrated as vasodilation to removal of bath Ca²⁺ with 5 mM EGTA, in a scrm control (black) and Rab25 siRNA (red) artery. D: mean data for scrm control and Rab25 siRNA arteries (n = 11 for scrm; n = 9 for Rab25 siRNA). *P < 0.05, compared with scrm control.