Figure 5.

Matrix metalloproteinase (MMP)-2/-9 in A549 cells. (a) Cells were incubated with curcumin or carboplatin as indicated for 24 h. MMP-2/-9 activities were examined using gelatin zymography. (b) Quantification of MMP-2/-9 activity by curcumin and/or carboplatin was compared with the control. Data are expressed as the mean ± SD. *, p < 0.05; ** p < 0.01; ***, p < 0.001 versus control group. ^#, p < 0.05 versus treatment group with 10 μM curcumin. ^$, p < 0.05; ^$$, p < 0.01 versus treatment group with 50 μM carboplatin; ^&, p < 0.05, ^&&, p < 0.01 versus treatment group with 100 μM carboplatin. (c) MMP-2/-9 mRNA levels were measured by RT-PCR analysis