Histopathological analysis of lung tissues among different groups is shown. (A, D) sham group, (B, E) control group, and (C, F) budisonide group. A–C: × 200; D–F: × 400. Lungs in the saline group showed thickened alveolar wall, edema and less alveolar space, and obvious inflammatory cell infiltration. Budesonide significantly decreased endotoxin-induced histopathological injury. (A color version of this figure is available in the online journal.)