Table 2.
Correlation of EZH2 expression with clinicopathological features in CRC
| EZH2 expression |
||||
|---|---|---|---|---|
| Clinicopathological parameters | Case no. | Low (%) | High (%) | P value |
| Total cases | 42 | 9 (21.4) | 33 (78.6) | |
| Age | >0.05 | |||
| ≤60 years | 19 | 4 (21.1) | 9 (78.9) | |
| >60 years | 23 | 7 (30.0) | 16 (70.0) | |
| Gender | >0.05 | |||
| Male | 26 | 7 (27.0) | 19 (73.0) | |
| Female | 16 | 6 (37.5) | 10 (72.5) | |
| BMI | >0.05 | |||
| ≥30 kg/m2 <30 kg/m2 | 8 34 | 2 (25.0) 7 (20.6) | 6 (75.0) 27 (79.4) | |
| Tumor size | >0.05 | |||
| ≤5 cm | 31 | 9 (29.0) | 22 (71.0) | |
| >5 cm | 11 | 2 (18.2) | 9 (81.8) | |
| Histological grade | >0.05 | |||
| Well differentiated | 10 | 3 (30.0) | 7 (70.0) | |
| Moderate differentiated | 18 | 5 (27.8) | 13 (72.2) | |
| Poor differentiated | 14 | 3 (21.4) | 11 (78.6) | |
| TNM stage | <0.01 | |||
| I II | 8 17 | 7 (85.7) 6 (35.3) | 1 (14.3) 11 (64.7) | |
| III IV | 12 5 | 2 (16.7) 2 (40.0) | 10 (83.3) 3 (60.0) | |
| Lymph node metastasis | <0.01 | |||
| Positive | 29 | 4 (13.8) | 25 (86.2) | |
| Negative | 13 | 6 (46.2) | 7 (53.8) | |
| Distant metastasis | >0.05 | |||
| Positive Negative | 5 37 | 2 (40.0) 12 (32.4) | 3 (60.0) 25 (67.6) | |
BMI: body mass index; CRC: colorectal cancer; TNM: tumor-lymph node-metastasis.