Table 2.
The effects of LA on total SOD, Mn SOD, and Cu/Zn SOD activity in mice various brain regionsa
| Enzyme activity(U/mg prot.) | Brain region | Groups |
|||
|---|---|---|---|---|---|
| Control | LA | MCD2 | MCD2 + LA | ||
| Total SOD | Cx | 7.61 ± 2.78 | 20.54 ± 2.21** | 2.03 ± 0.33** | 24.20 ± 4.36**,## |
| H | 8.76 ± 3.27 | 19.21 ± 4.32** | 2.38 ± 0.30** | 21.86 ± 4.10**,## | |
| S | 9.30 ± 2.03 | 16.11 ± 2.21** | 2.54 ± 0.27** | 15.11 ± 5.47*,## | |
| Hipp | 8.28 ± 4.07 | 11.23 ± 3.11* | 2.67 ± 0.66** | 13.06 ± 5.49## | |
| Mn SOD | Cx | 2.64 ± 0.21 | 3.56 ± 0.32** | 0.90 ± 0.16* | 3.08 ± 1.11## |
| H | 4.13 ± 1.30 | 4.71 ± 0.21* | 1.35 ± 0.10** | 4.79 ± 0.10## | |
| S | 4.72 ± 1.01 | 5.66 ± 1.00* | 1.12 ± 0.11* | 5.46 ± 1.20## | |
| Hipp | 1.63 ± 0.65 | 4.12 ± 0.66** | 1.47 ± 0.62 | 4.97 ± 0.87**,## | |
| Cu/Zn SOD | Cx | 4.97 ± 1.61 | 13.32 ± 2.45** | 0.83 ± 0.24** | 21.67 ± 7.75**,## |
| H | 4.85 ± 1.64 | 8.01 ± 0.76* | 1.21 ± 0.41** | 4.86 ± 1.37## | |
| S | 4.86 ± 1.42 | 13.65 ± 1.76** | 1.22 ± 0.49** | 15.91 ± 4.26**,## | |
| Hipp | 5.69 ± 2.39 | 6.88 ± 2.21 | 1.44 ± 0.54** | 6.25 ± 2.49## | |
Cx: cortex; H: Hypothalamus; S: striatum; Hipp: hippocampus; MCD: methionine–choline deficient; LA: lipoic acid; SOD: superoxide dismutase; control: continuously fed with standard chow; LA: group fed with standard chow and was receiving LA for two weeks; MCD2: group fed with MCD diet for two weeks; MCD2 + LA: group that was fed with MCD diet for two weeks and was receiving LA.
a
Significance of the difference was estimated by using one-way ANOVA with Tukey’s post hoc test (*P < 0.05, **P < 0.01 vs. control; ##P < 0.01 vs. MCD2 group).