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GPR40 deficiency sustains bone status in surgical-induced OA mice. The bone formation marker, N-terminal fragment of collagen 1 (PINP), and the bone resorption marker, C-terminal fragment (CTX-1), were detected in mouse sera. Results are presented as mean ± SEM; *, #: P < 0.05, non-parametric Mann–Whitney test (n = 5 per group). (*) and (#) and indicate significant differences compared to sham-operated GPR40+/+ group and PMMx-GPR40+/+ group, respectively
