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Inhibition of LOX reduced DNA repair in hypoxic A549 cells. (a) A549 cells were cultured in hypoxic or normoxic conditions with or without 200 μM βAPN as indicated. Representative images of nuclei (blue) and γ-H2AX (red) complexes are shown. (b) Quantification of the H2AX foci per nucleus from at least three independent measurements are presented as mean ± SEM.*p < 0.05; **p < 0.01. (A color version of this figure is available in the online journal.)
