Figure 8.

HO-1 expression induced by SCF4 blocked the LPS-induced inflammation activated by STAT1 signaling. (a) Phosphorylation of STAT1 decreased following treatment with SCF4. (b) Inhibitory effects of SCF4 on LPS-induced STAT1 signaling were diminished following treatment with ZnPP. Results of the western blot analysis represent three independent experiments that yielded similar results. Data are the means ± SEM (n = 3), *p < 0.05. HO-1: heme oxygenase-1; LPS: lipopolysaccharide; SCF4: subfraction 4 of the n-hexane layer of the EtOH extract of the aerial parts of S. chinensis; SEM: standard error of the mean; STAT: signal transducer and activator of transcription; ZnPP: zinc protoporphyrin