Figure 2.

Modulation of the OGF-OGFr axis alters the numbers of CD4⁺T lymphocytes present in the CNS of mice with established EAE. (a) Percent of total cells that are CD4⁺ isolated from CNS tissue of EAE mice treated with OGF, LDN or saline for five days from disease onset. (b) Number of CD4⁺ T lymphocytes isolated from the CNS of EAE mice. Significantly different from EAE + SALINE at p < 0.01 (**), p < 0.001 (***), and p < 0.0001 (****). Significantly different from EAE + OGF at p < 0.0001 (++++).

EAE: experimental autoimmune encephalomyelitis; OGF: opioid growth factor; LDN: low dosage of naltrexone