Figure 2.

The fat pad weight and insulin sensitivity at different time points in each group. (a) The left side epididymal fat pad weight (n = 4–5). (b) The insulin sensitivity was detected by euglycemic–hyperinsulinemic clamp technique and presented with glucose infusion rate (GIR). (n = 5) NFal—feed ad libitum with normal chow diet, HFal—feed ad libitum with high-fat diet, HFal-NFcr—caloric restriction with normal chow diet after HFal for two months and HFal-NFcr-NFal—refeeding ad libitum with normal chow diet after CR for two months. 4 M, 6 M, and 8 M: the age of four, six, and eight months old. **: P < 0.01 versus other groups at the same age; ##: P < 0.01 versus the same groups at different ages. All values are means ± S.E