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. 2016 Jun 9;38(2):446–456. doi: 10.3892/ijmm.2016.2634

Figure 1.

Figure 1

Identification of microRNAs (miRNAs or miRs) differentially expressed in childhood asthma. (A) Volcano plot presents differential expression of miRNAs. The vertical lines corresponds to fold changes of -2 (downregulation) and +2 (upregulation). The horizontal line represents a p-value of 0.05. The red points in the plot represent the differentially expressed miRNAs with statistical significance. There were 112 upregulated and 10 downregulated miRNAs identified. (B) A heat map shows a main part of the clustering of miRNAs. Upregulated miRNAs are colored red, and downregulated are green. The expression of miR-513a-5p, miR-22-3p and miR-625-5p was downregulated in the asthma group compared with the control group (p<0.05). miR-625-5p was changed 2.17-fold, miR-513a-5p was changed 2.07-fold and miR-22-3p was changed 2.21-fold in the asthma group. (C) miRNA-target genes are co-regulated by multi-miRNAs. Three target genes were co-regulated by miR-513a-5p, miR-22-3p and miR-625-5p, and three pairs of any two miRNAs combined may have 12 target genes co-regulated individually.