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. 2016 May 6;310(11):L1243–L1259. doi: 10.1152/ajplung.00396.2015

Fig. 10.

Fig. 10.

Therapeutic regimen of TUDCA attenuates HDM-induced ER stress and AHR, regardless of HDM rechallenge. A–D: mRNA expression analysis of ER stress marker genes in lung lysates of vehicle-treated and TUDCA-treated HDM-challenged mice. Data were normalized to the housekeeping gene GAPDH. Data are means ± SE of 6–8 mice/group. *P < 0.05 compared with their respective PBS controls. #P < 0.05 compared with vehicle-treated HDM-challenged mice. E–G: analysis of methacholine-induced AHR in mice. Data are means ± SE of 6–8 mice/group. *P < 0.05 compared with their respective PBS controls and #P < 0.05 compared with vehicle-treated HDM-challenged mice. ‡P < 0.05 compared with HDM-challenged mice treated with 0.75 mg/kg TUDCA.