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. 2016 May 6;310(11):L1243–L1259. doi: 10.1152/ajplung.00396.2015

Fig. 12.

Fig. 12.

Therapeutic regimen of TUDCA decreases HDM-induced airway fibrotic remodeling, regardless of HDM rechallenge. A: representative images of α-SMA-stained lung tissue sections of vehicle-treated and TUDCA (0.75 mg/kg body wt dose)-treated HDM-challenged mice (×20 magnification; scale bars = 50 μm) and the quantification of percentage of area that positively stained for α-SMA immunostaining. Data are means ± SE of 6–8 mice/group. *P < 0.05 compared with their respective PBS controls and #P < 0.05 compared with vehicle-treated HDM-challenged mice. ‡P < 0.05 compared with HDM-challenged mice treated with 0.75 mg/kg TUDCA. B: measurement of collagen by hydroxyproline assay. Data are means ± SE of 6–8 mice/group. *P < 0.05 compared with their respective PBS controls and #P < 0.05 compared with vehicle-treated HDM-challenged mice. ‡P < 0.05 compared with HDM-challenged mice treated with 0.75 mg/kg TUDCA.