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. 2016 May 6;310(11):L1243–L1259. doi: 10.1152/ajplung.00396.2015

Fig. 3.

Fig. 3.

Preventive regimen of TUDCA downregulates HDM-induced increases in mucus genes and mitigates mucus metaplasia. A–C: mRNA expression analysis of the genes associated with mucus production and secretion, in whole lung lysates of vehicle-treated and TUDCA-treated HDM-challenged mice. Data were normalized to the housekeeping gene Gapdh. Data are means ± SE of 6–8 mice/group. *P < 0.05 compared with their respective PBS controls and #P < 0.05 compared with vehicle-treated HDM-challenged mice. D: representative images of periodic acid-Schiff (PAS)-stained lung tissue sections of vehicle-treated or untreated and TUDCA (1 mg/kg body wt dose)-treated HDM-challenged (×20 magnification; scale bars = 50 μm) mice and the quantification of percentage of area that positively stained for PAS staining. Data are means ± SE of 6–8 mice/group. *P < 0.05 compared with their respective PBS controls. #P < 0.05 compared with vehicle-untreated HDM-challenged mice. ‡P < 0.05 compared with vehicle-treated HDM-challenged mice.