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. 2016 May 6;310(11):L1243–L1259. doi: 10.1152/ajplung.00396.2015

Fig. 7.

Fig. 7.

Therapeutic regimen of TUDCA downregulates the expression of HDM-induced mucin genes and mucus production. A–C: mRNA analysis of the genes associated with mucus production and secretion in whole lung lysates of vehicle-treated and TUDCA-treated HDM-challenged mice. Data are means ± SE of 5–6 mice/group. *P < 0.05 compared with their respective PBS controls. #P < 0.05 compared with vehicle-treated HDM-challenged mice. ‡P < 0.05 compared with mice treated with 0.25 mg/kg TUDCA. D: representative images of PAS-stained lung tissue sections of vehicle-treated or untreated and TUDCA-treated HDM-challenged mice (×20 magnification; scale bars = 50 μm) and the quantification of percentage of area that positively stained for PAS staining. *P < 0.05 compared with their respective PBS controls. #P < 0.05 compared with vehicle-treated HDM-challenged mice. ‡P < 0.05 compared with mice treated with 0.25 mg/kg TUDCA. §P < 0.05 compared with mice treated with 5 mg/kg TUDCA.