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. 2016 May 6;310(11):L1243–L1259. doi: 10.1152/ajplung.00396.2015

Fig. 9.

Fig. 9.

Therapeutic regimen of TUDCA decreases HDM-induced airway infiltration of inflammatory cells and decreases inflammatory cytokines and chemokines, regardless of HDM rechallenge. A: schematic representing the time points of HDM or PBS instillation and TUDCA treatment. HDM (25 μg/mouse) was instilled intranasally while TUDCA (0.75 mg/kg body wt) was administered via nasopharynx after the HDM challenge phase. B–F: analysis of inflammatory and immune cells in the BALF. Data are means ± SE of 6–8 mice/group. *P < 0.05 compared with their respective PBS controls. #P < 0.05 compared with vehicle-treated HDM-challenged mice. ‡P < 0.05 compared with HDM-challenged mice treated with 0.75 mg/kg TUDCA. G–M: ELISA for cytokines and chemokines. Data are means ± SE of 6–8 mice/group. *P < 0.05 compared with their respective PBS controls. #P < 0.05 compared with vehicle-treated HDM-challenged mice. ‡P < 0.05 compared with HDM-challenged mice treated with 0.75 mg/kg TUDCA.