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. 2016 Mar 31;310(11):G1015–G1027. doi: 10.1152/ajpgi.00349.2015

Fig. 3.

Fig. 3.

Effect of PP2 and PP3 on CCK-mediated secretion of macrophage inflammatory protein (MIP)-2 or monocyte chemotactic protein-1 (MCP-1) in pancreatic acinar cells. Freshly isolated rat pancreatic acini were preincubated with either 10 μM PP2 or PP3 for 1 h followed by stimulation with 100 nM CCK for 2 h as described above. The supernatant was used to measure MIP-2 (A) and MCP-1 (B) levels by ELISA as described in materials and methods. Results shown are means ± SE of 4 independent experiments. The basal absolute values for chemokine release in the pancreatic acinar were 0.75 ± 0.21 ng/ml for MIP-2 and 0.62 ± 0.11 ng/ml for MCP-1. *P < 0.05 for CCK, PP2-CCK, or PP3-CCK compared with control, PP2, or PP3 alone, respectively. #P < 0.05, PP2 preincubated cells vs. control.