Fig. 5.

Effect of inhibition of SFK on CCK-mediated lactate dehydrogenase (LDH) release in pancreatic acini. Freshly isolated rat pancreatic acini were preincubated with either 10 μM PP2 or PP3 for 1 h followed by stimulation with 100 nM CCK for 2 h. Acinar cell necrosis was measured by the percentage of total LDH released in the medium, as described in materials and methods. Results are representative of 4 independent (n = 4) experiments. Results shown are means ± SE. *P < 0.05 comparing control, PP2, or PP3 alone vs. CCK, PP2-CCK, or PP3-CCK, respectively.