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Effect of inhibition of SFK on CCK-mediated trypsin activation in pancreatic acini. Freshly isolated rat pancreatic acini were preincubated with either 10 μM PP2 or PP3 for 1 h followed by stimulation with 100 nM CCK for 20 min. Trypsin activity was measured as described in materials and methods in the lysates of isolated pancreatic acini. Results shown are means of 4 independent experiments. *P < 0.05 vs. control, #P < 0.05 vs. PP2 alone, and ∞P < 0.05 vs. PP3 alone.
