Table 1.

SFK role in some physiological and pathophysiological functions in rat pancreatic acini

Variable	Yes	No
Signaling cascade activation
Stimulated by 100 nM CCKa	SFK, p42/44, JNK
Basal inhibition by PP2a	SFK	p42/44, JNK
PP2 inhibition of CCK-induced stimulationa		SFK, p42/44, JNK
Transcription factor activation
100 nM CCK inducedb	STAT3, NF-κB, and AP-1
PP2 inhibition of basalb		STAT3, NF-κB, AP-1
PP2 inhibition of CCK inducedb	STAT3, NF-κB, and AP-1
Chemokine release
Stimulated by 100 nM CCKc,d	MCP-1, MIP-1α, RANTES	MIP-2.
Basal inhibition by PP2c,d	MIP-1, MCP-1	MIP-1-α, RANTES
PP2 inhibition of CCK-induced stimulationc,d	MCP-1, MIP-1α, RANTES	MIP-2
LDH release
100 nM CCK inducede	Stimulation of 237 ± 32% over control
PP2 inhibition of basale		No effect vs. control
PP2 inhibition of CCK inducede	−59 ± 7%Δ of CCK alone
Cell death caspases activity
100 nM CCKf	Caspase-3, -8, and -9
PP2 stimulation of basalf	Caspase-3, -8, and -9
PP2 inhibition of CCK-induced LDH releasef	Caspase-3, -8, and -9
Trypsinogen activationg	Stimulated by 100 nM CCK	Not inhibited by PP2
Amylase releaseh	Stimulated by CCK at 0.01, 0.1, and 100 nM	Not inhibited by PP2 at any concentration

SFK, Src family of kinases; JNK, c-Jun-NH₂-terminal kinase; CCK, COOH-terminal octapeptide of cholecystokinin; PP2, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine; STAT3, signal transducer and activator of transcription-3; AP-1, activator protein-1; MCP-1, monocyte chemotactic protein-1; MIP, macrophage inflammatory protein; RANTES, regulated on activation, normal T cell expressed and secreted.

^aResults are calculated from the data shown in Fig. 1.

^bConcentration and incubation times are reported in Fig. 2.

^cConcentration and incubation times are reported in Fig. 3.

^dConcentration and incubation times are reported in Fig. 4.

^eConcentration and incubation times are reported in Fig. 5.

^fConcentration and incubation times are reported in Fig. 6.

^gConcentration and incubation times are reported in Fig. 7.

^hConcentration and incubation times are reported in Tables 2 and 3.