Table 2.

Effect of Src inhibition on amylase secretion induced by different CCK concentrations

	Amylase Secretion, %total
Secretagogue	No PP2/PP3	PP2 (10 μM)	PP3 (10 μM)
None	6.1 ± 0.6	5.2 ± 1.2	5.9 ± 0.5
CCK, nM
0.01	8.4 ± 1.1	8.9 ± 0.4	8.3 ± 0.8
0.1	12.4 ± 1.2	13.9 ± 0.5	13.3 ± 0.7
100	10.4 ± 0.4	10.7 ± 0.6	10.5 ± 0.4

Pancreatic acini were incubated with no additions, and three different concentrations of CCK (0.01, 0.1, and 100 nM) alone or with the active SFK inhibitor PP2 (10 μM) or its inactive analog PP3 (10 μM). PP3, 4-amino-7-phenylpyrazol[3,4-d]pyrimidine.