Table 3.

Effect of Src inhibition on amylase secretion by different PP2 concentrations

	Amylase Secretion, %total
Secretagogue	No PP2/PP3	PP2 (10 nM)	PP2 (100 nM)	PP2 (1 μM)	PP3 (1 μM)
None	6.0 ± 0.8	6.7 ± 0.7	6.1 ± 0.9	7.2 ± 0.5	7.1 ± 0.6
CCK, nM
0.1	13.6 ± 1.7	14.7 ± 1.3	14.5 ± 1.2	15.1 ± 1.0	14.4 ± 1.1
100	11.3 ± 2.1	12.2 ± 1.4	11.7 ± 1.8	12.3 ± 1.0	11.4 ± 1.2

Pancreatic acini were incubated with no additions and three different concentrations of PP2 (10 nM, 100 nM, and 1 μM) alone or with CCK (0.1 and 100 nM). Amylase release, expressed, as %cellular total amylase was determined after 30 min incubation. Results are averages of 5 experiments.