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Significant loss of DRA protein levels in the cecum, proximal and distal colon of K8−/− mice. Western blot showed prominent DRA downregulation in cecum (A) and proximal (B) and distal colon (C). DRA levels were quantified and normalized to the housekeeping gene GAPDH (D–F). DRA levels were significantly lower in K8+/− proximal colon and almost absent in K8−/− colon and cecum compared with K8+/+ mice (n = 3; *P < 0.05, ***P < 0.001). Mouse K8 genotype was determined by PCR (not shown).
