Fig. 4.

Reexpression of LepR selectively in GnRHR cells causes no improvement of the reproductive phenotype of LepR^loxTB mice. A–C: bright-field images showing hematoxylin and eosin stained sections of the ovary of controls in diestrus (A), LepR^loxTB (B), and GRIC LepR^loxTB (C) mice. Note the presence of corpus luteum (CL) only in the ovary of the control mouse. D: digital image showing the uterine morphology of controls in diestrus, LepR^loxTB, and GRIC LepR^loxTB mice. E: bar graphs comparing uterus weight of controls in diestrus (n = 11), LepR^loxTB (n = 11), and GRIC LepR^loxTB (n = 5) adult mice. No difference between uterus weight of LepR^loxTB and GRIC LepR^loxTB mice was observed. ****P < 0.001 compared with wild-type control mice per one-way ANOVA, Tukey's post hoc multiple comparison test. Scale bar: 1 mm.