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. 1970 Oct;33(5):687–693. doi: 10.1136/jnnp.33.5.687

Familial centronuclear myopathy

W G Bradley 1,2,3,1, D L Price 1,2,3, C K Watanabe 1,2,3
PMCID: PMC493550  PMID: 5478951

Abstract

The clinical and histological features of two Negro brothers with a centronuclear myopathy are described. They bring to 19 the number of cases now reported with this constellation of physical signs and pathological changes in the muscles. A review of these patients suggests the existence of several different diseases causing this picture, though presumably the underlying biochemical defects are closely related. It is concluded that these myopathies are degenerative rather than due to arrest of foetal muscle maturation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Badurska B., Fidziańska A., Kamieniecka Z., Prot J., Strugalska H. Myotubular myopathy. J Neurol Sci. 1969 May-Jun;8(3):563–571. doi: 10.1016/0022-510x(69)90014-8. [DOI] [PubMed] [Google Scholar]
  2. Bethlem J., Meijer A. E., Schellens J. P., Vroom J. J. Centronuclear myopathy. Eur Neurol. 1968;1(6):325–333. doi: 10.1159/000113672. [DOI] [PubMed] [Google Scholar]
  3. Bethlem J., van Wijngaarden G. K., Meijer A. E., Hülsmann W. C. Neuromuscular disease with type I fiber atrophy, central nuclei, and myotube-like structures. Neurology. 1969 Jul;19(7):705–710. doi: 10.1212/wnl.19.7.705. [DOI] [PubMed] [Google Scholar]
  4. Campbell M. J., Rebeiz J. J., Walton J. N. Myotubular, centronuclear or Peri-Centronuclear myopathy? J Neurol Sci. 1969 May-Jun;8(3):425–443. doi: 10.1016/0022-510x(69)90003-3. [DOI] [PubMed] [Google Scholar]
  5. Duchen L. W. Changes in motor innervation and cholinesterase localization induced by botulinum toxin in skeletal muscle of the mouse: differences between fast and slow muscles. J Neurol Neurosurg Psychiatry. 1970 Feb;33(1):40–54. doi: 10.1136/jnnp.33.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Engel W. K., Gold G. N., Karpati G. Type I fiber hypotrophy and central nuclei. A rare congenital muscle abnormality with a possible experimental model. Arch Neurol. 1968 Apr;18(4):435–444. doi: 10.1001/archneur.1968.00470340121011. [DOI] [PubMed] [Google Scholar]
  7. Engel W. K. Selective and nonselective susceptibility of muscle fiber types. A new approach to human neuromuscular diseases. Arch Neurol. 1970 Feb;22(2):97–117. doi: 10.1001/archneur.1970.00480200003001. [DOI] [PubMed] [Google Scholar]
  8. Kinoshita M., Cadman T. E. Myotubular myopathy. Arch Neurol. 1968 Mar;18(3):265–271. doi: 10.1001/archneur.1968.00470330055005. [DOI] [PubMed] [Google Scholar]
  9. Ortiz de Zarate J. C., Maruffo A. The descending ocular myopathy of early childhood; myotubular or centronuclear myopathy. Eur Neurol. 1970;3(1):1–12. doi: 10.1159/000113955. [DOI] [PubMed] [Google Scholar]
  10. Sher J. H., Rimalovski A. B., Athanassiades T. J., Aronson S. M. Familial centronuclear myopathy: a clinical and pathological study. Neurology. 1967 Aug;17(8 Pt 1):727–742. doi: 10.1212/wnl.17.8.727. [DOI] [PubMed] [Google Scholar]
  11. Spiro A. J., Shy G. M., Gonatas N. K. Myotubular myopathy. Persistence of fetal muscle in an adolescent boy. Arch Neurol. 1966 Jan;14(1):1–14. doi: 10.1001/archneur.1966.00470070005001. [DOI] [PubMed] [Google Scholar]
  12. van Wijngaarden G. K., Fleury P., Bethlem J., Meijer A. E. Familial "myotubular" myopathy. Neurology. 1969 Sep;19(9):901–908. doi: 10.1212/wnl.19.9.901. [DOI] [PubMed] [Google Scholar]

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