Fig. 2.
Examples of the effects of continuous infusion of hydrogen sulfide (H2S; 12 μmol/min for 4.5 min) on end-systolic and end-diastolic left ventricular diameter, left ventricular ejection fraction (EF), arterial blood pressure (ABP), and oxygen uptake (V̇o2) in two urethane-anesthetized rats. Left: response of an untreated animal (saline, S), wherein H2S infusion provoked a rapid reduction in cardiac contractility along with a drop in blood pressure and V̇o2 leading to complete electromechanical dissociation (PEA). Right: time course of the same variables in an animal treated with methylene blue (MB) injections (4 mg/kg, vertical arrows). Note that MB allowed the maintenance of cardiac contractility and hemodynamics until the end of infusion.