Fig. 9.

Coronary flow during cardiac pacing with β-adrenoceptor receptor blockade. Model prediction (solid line) is compared to data (squares) on coronary flow (F) vs. myocardial oxygen consumption (M) during cardiac pacing with β-adrenoceptor receptor blockade (39). For this simulation, M was varied from 71 to 140 μl O₂⁻¹·min¹·g¹. Arterial pressure was varied according to P = (0.188 mmHg·μl O₂⁻¹·min¹·g¹)M + 90.623 mmHg, to match the observed pressures of 104 mmHg during single pacing and 117 mmHg during paired pacing. The open-loop signal was set to zero (K_ol = 0).