Table 2.
Study group characteristics in alcoholic cardiomyopathy
Variable | Pair-fed | EtOH 10d | EtOH 10d 1B | EtOH 20d | EtOH 20d 2B | EtOH 40d | EtOH 40d 4B |
---|---|---|---|---|---|---|---|
Body weight, g | 26.3 ± 0.4 | 25.0 ± 0.07 | 26.1 ± 0.7 | 26.3 ± 0.08 | 26.6 ± 0.5 | 27.8 ± 0.6 | 26.4 ± 0.6 |
Heart weight/tibia length, mg/mm | 6.5 ± 0.1 | 6.9 ± 0.02 | 6.4 ± 0.2 | 6.7 ± 0.5 | 6.2 ± 0.5 | 7.3 ± 0.1 | 6.6 ± 0.2 |
Heart weight/body weight, mg/g | 5.0 ± 0.1 | 5.4 ± 0.2 | 4.6 ± 0.1# | 4.8 ± 0.4 | 4.4 ± 0.3 | 4.9 ± 0.1 | 4.8 ± 0.1 |
Tibial length, mm | 19.3 ± 0.3 | 18.8 ± 0.3 | 18.9 ± 0.1 | 18.9 ± 0.2 | 18.9 ± 0.3 | 19.0 ± 0.4 | 19.0 ± 0.3 |
Heart rate, beats/min | 599 ± 10 | 616 ± 7 | 490 ± 13*# | 608 ± 10 | 511 ± 18*# | 623 ± 12 | 504 ± 19*# |
Values are means ± SE. The table shows the basic characteristic of the study groups. Groups: Pair-fed (isocalorically fed with Lieber-DeCarli control liquid diet), ethanol (EtOH) Lieber-DeCarli liquid diet containing 5% (vol/vol) EtOH for 10 days (EtOH 10d); for 20 days (EtOH 20d); for 40 days (EtOH 40d); liquid diet containing 5% (vol/vol) EtOH for 10 days and binge feeding on day 11 with 5 g/kg body wt EtOH solution (EtOH 10d 1B); for 20 days combined with binge feeding on days 11 and 21 with 5 g/kg body wt EtOH solution (EtOH 20d 2B); for 40 days combined with binge feeding on days 11, 21, 31, and 41 with 5 g/kg body wt EtOH solution (EtOH 40d 4B).
P < 0.05 vs. Pair-fed;
P < 0.05 vs. corresponding chronic EtOH-fed group.