Table 3.
Echocardiography parameters in alcoholic cardiomyopathy
| Variable | Pair-fed | EtOH 10d | EtOH 10d 1B | EtOH 20d | EtOH 20d 2B | EtOH 40d | EtOH 40d 4B |
|---|---|---|---|---|---|---|---|
| Ejection fraction, % | 60 ± 3 | 64 ± 3 | 64 ± 1 | 61 ± 2 | 63 ± 3 | 63 ± 3 | 62 ± 2 |
| Fractional shortening, % | 33.8 ± 2.0 | 36.5 ± 3.4 | 33.2 ± 0.7 | 29.9 ± 0.6 | 32.4 ± 1.6 | 30.6 ± 3.5 | 33.9 ± 0.5 |
| LVAWd, mm | 0.80 ± 0.04 | 0.89 ± 0.01 | 0.81 ± 0.03 | 0.81 ± 0.03 | 0.78 ± 0.03 | 0.97 ± 0.03* | 0.93 ± 0.03* |
| LVAWs, mm | 1.02 ± 0.03 | 1.26 ± 0.05* | 1.19 ± 0.03* | 1.20 ± 0.05* | 1.19 ± 0.05* | 1.38 ± 0.04* | 1.34 ± 0.04* |
| LVIDd, mm | 3.78 ± 0.07 | 3.44 ± 0.14 | 3.63 ± 0.12 | 3.72 ± 0.05 | 3.62 ± 0.07 | 3.58 ± 0.09 | 3.49 ± 0.09 |
| LVIDs, mm | 2.64 ± 0.12 | 2.25 ± 0.19 | 2.47 ± 0.09 | 2.61 ± 0.03 | 2.45 ± 0.08 | 2.48 ± 0.12 | 2.39 ± 0.04 |
| LVPWd, mm | 0.75 ± 0.02 | 0.78 ± 0.02 | 0.90 ± 0.04*# | 0.81 ± 0.04 | 0.93 ± 0.04* | 0.81 ± 0.04 | 0.88 ± 0.04* |
| LVPWs, mm | 1.00 ± 0.03 | 1.08 ± 0.03 | 1.18 ± 0.06* | 1.11 ± 0.05 | 1.22 ± 0.09* | 1.10 ± 0.04 | 1.17 ± 0.06* |
| E/A ratio | 1.51 ± 0.07 | 1.54 ± 0.26 | 1.61 ± 0.16 | 1.57 ± 0.29 | 1.37 ± 0.07 | 1.43 ± 0.05 | 1.37 ± 0.08 |
| LVmass, mg | 106.3 ± 4.5 | 100.1 ± 5.5 | 105.7 ± 7.8 | 105.6 ± 6.4 | 105.0 ± 7.0 | 111.3 ± 7.3 | 105.9 ± 5.1 |
| Relative wall thickness (LVAWd + LVPWd/LVIDd) | 0.41 ± 0.02 | 0.46 ± 0.02 | 0.46 ± 0.02 | 0.44 ± 0.01 | 0.46 ± 0.02 | 0.50 ± 0.02* | 0.51 ± 0.02* |
Values are means ± SE. The table shows the results of the following echocardiographic parameters in alcoholic cardiomyopathy: ejection fraction, fractional shortening, left ventricular (LV) anterior wall thickness in diastole (LVAWd), LVAW thickness in systole (LVAWs), LV internal diameter in diastole (LVIDd), LVID in systole (LVIDs), LV posterior wall thickness in diastole (LVPWd), LVPW in systole (LVPWs), ratio of the early (E) to late (A) ventricular filling velocities (E/A ratio), LVmass, and relative wall thickness. Groups: Pair-fed (isocalorically fed with Lieber-DeCarli control liquid diet), ethanol (EtOH) Lieber-DeCarli liquid diet containing 5% (vol/vol) EtOH for 10 days (EtOH 10d); for 20 days (EtOH 20d); for 40 days (EtOH 40d); liquid diet containing 5% (vol/vol) EtOH for 10 days and binge feeding on day 11 with 5 g/kg body wt EtOH solution (EtOH 10d 1B); for 20 days combined with binge feeding on days 11 and 21 with 5 g/kg body wt EtOH solution (EtOH 20d 2B); for 40 days combined with binge feeding on days 11, 21, 31, and 41 with 5 g/kg BW EtOH solution (EtOH 40d 4B)
P < 0.05 vs. Pair-fed
P < 0.05 vs. corresponding chronic EtOH-fed group.