Table 6.

Transcripts identified in microarray screen associated with cardiovascular function

Gene	LRVAS vs. WTVAS	LRVAD vs. WTVAS	Function
Angpt2	−1.4 (0.003) FDR = 0.42	−1.5 (0.0006) FDR = 0.42	Angiopoietin 2 is significantly increased in acute decompensated heart failure and is a predictor of poor outcome (41)
Casq2	−1.1 (0.10) FDR = 0.43	−1.5 (0.0007) FDR = 0.43	Calsequestrin 2 buffers sarcoplasmic reticulum Ca2+ ions and regulates ryanodine receptor (42)
Mgp	1.6 (0.002) FDR = 0.46	1.6 (0.0012) FDR = 0.46	Matrix Gla protein is a calcification inhibitor protein; may have a role in left ventricular dysfunction in patients with symptomatic aortic stenosis (52)
Npr1	−1.4 (0.003) FDR = 0.50	−1.5 (0.002) FDR = 0.50	Natiuretic peptide receptor 1
Npy	1.5 (0.006) FDR = 0.50	1.8 (0.0011) FDR = 0.50	Neuropeptide Y is expressed in heart neurons and endothelial cells; its extensive actions are mediated through NPY1 and NPY6 receptors; the Y1 receptor induces vasoconstriction and regulates gene expression in hypertrophying cardiomyocytes (18)
S100a1	−1.5 (0.0006) FDR = 0.34	−1.6 (0.0005) FDR = 0.34	S100 calcium-binding protein A1 is the most abundant member of the calcium-binding S100 protein family in myocardial tissue; serves important roles in energy balance, myofilament sliding, myofilament calcium sensibility, titin-actin interaction, apoptosis, and cardiac remodeling (17)

Shown here are results observed in only the left ventricle. Values in bold represent significant fold change in transcript expression relative to WTVAS control tissues; P values are indicated in parentheses.

ns, not significantly different than WTVAS.

Values in unbolded font failed 1 of 3 parameters for significance but are included to show trends.