Table 7.
Genes not associated with cardiovascular function whose transcripts were significantly affected by VA status in RV
| Gene | LRVAS vs. WTVAS | LRVAD vs. WTVAS | Function |
|---|---|---|---|
| Genes associated with cell adhesion/interaction/cytoskeletal | |||
| Limch1, LIM and calponin homology domains 1 | 1.4 | 1.6 | Actin binding domain |
| Pdpn, podoplanin | −1.5 | −1.5 | Type-I integral membrane glycoprotein with diverse distribution in human tissues |
| Genes associated with energy balance | |||
| Cox18, cytochrome c oxidase assembly protein 18 | −1.5 | −1.5 | Assembly of mitochondrial oxidative phosphorylation protein |
| Pfkfb1, 6-phosphofructo-2-kinase | 1.4 | 2.0 | Glycolysis |
| Genes Associated with Immune System and Function | |||
| Retnla, resistin like α | −1.9 | −3.7 | Immunity, inflammation |
| Genes associated with growth and differentiation | |||
| Lgr6, leucine-rich repeat containing G protein-coupled receptor 6 | 3.1 | 3.3 | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis |
| Tcea3, transcription elongation factor A (SII), 3 | −1.5 | −1.5 | Suppression of Tcea3 shifts mouse embryonic stem cells from pluripotency into enhanced mesoderm development, and vasculogenesis factors are activated |
| Genes encoding receptors, channels, and signaling proteins | |||
| Itpripl2 | 1.2 | 1.5 | Inositol 1,4,5-triphosphate receptor interacting protein |
| Olfr872 | −4.6 | −4.7 | Olfactory receptor 872 |
| Ptgfr | −1.6 | −1.4 | Prostaglandin F receptor |
| Rsg1 | −1.5 | −1.4 | REM2 and RAB-like small GTPase 1 |
| Tmc7 | 1.5 | 1.7 | Transmembrane channel-like gene family 7 |
| Genes encoding enzymes | |||
| Aoah | −1.7 | −1.4 | Acyloxyacyl hydrolase |
| Mboat2 | −2.7 | −2.2 | Membrane bound O-acyltransferase domain containing 2 |
| Atp10d | −1.5 | −1.6 | ATPase, class V, type 10D |
| Gdpd3 | −27.3 | −25.1 | Glycerophosphodiester phosphodiesterase domain containing 3 |
| Glo1 | −1.6 | −1.6 | Glyoxalase 1 |
| Mettl21d | 1.5 | 1.5 | Methyltransferase like 21D |
| Ubiad1 | −1.7 | −1.4 | UbiA prenyltransferase domain containing 1 |
| Genes encoding other proteins | |||
| Elovl7, ELOVL family member 7 | −3.4 | −3.9 | Elongation of long-chain fatty acids |
| Hn1l | −1.6 | −1.6 | Hematological and neurological expressed 1-like |
| Park2 | −1.6 | −2.1 | Parkinson's disease (autosomal recessive, juvenile) 2 |
| Pkd2l2 | −1.7 | −1.7 | Polycystic kidney disease 2-like 2 |
| Rsph3a/b | 1.8 | 2.1 | Radial spoke 3A homolog (Chlamydomonas) |
| Sfrp2 | −1.7 | −1.4 | Secreted frizzled-related protein 2 |
| Zfp87 | −1.5 | −1.5 | Zinc finger protein 87 |
Values in bold font are significantly affected by VA status in RV. Values in unbolded font failed 1 of 3 tests for significance.