Table 8.
Genes not known to be associated with cardiovascular function whose transcripts were significantly affected by VA status in LV
| Gene | LRVAS vs. WTVAS | LRVAD vs. WTVAS | Function |
|---|---|---|---|
| Genes associated with energy balance | |||
| Atp5e, ATP synthase, H+ transporting, mitochondrial F1 complex | 1.4 | 1.5 | Encodes a subunit of mitochondrial ATP synthase |
| Genes associated with immunity and inflammation | |||
| Cd24a antigen | 1.8* | 2.5* | |
| Cd38 antigen | −1.6† | ||
| Cd209a antigen | −5.5 | −5.6 | RA induces Cd209 |
| Clec2e, C-type lectin domain family 2, member e | 1.8 | 2.0 | Lectin-like receptor expressed in myeloid cells and NK cells |
| Colec11, collectin subfamily member 11 | −1.8 | −1.7 | COLEC11 genes encode soluble pattern recognition molecules in the lectin pathway of complement |
| Ifi44l | 2.2 | 2.6 | Interferon-induced protein 44 like |
| Klrb1b | 1.4 | 1.5 | Killer cell lectin-like receptor subfamily B member 1B |
| Lect1 | −2.8 | −2.9 | Leukocyte cell-derived chemotaxin |
| Genes associated with cell proliferation | |||
| Mki67, antigen identified by monoclonal antibody Ki-67 | 1.4‡ | Cellular marker for proliferation | |
| Genes associated with chromosome organization | |||
| H2afj, H2A histone family, member J | 1.3 | 1.5 | |
| Mcm6, minichromosome maintenance deficient 6 | 1.9 | 2.2 | |
| Rsl1, regulator of sex-limited protein 1 | −2.1 | −2.2 | Zinc finger regulatory transcription repression factor; regulates sex- and tissue-specific promoter methylation and dynamic hormone-responsive chromatin configuration |
| Genes associated with growth, differentiation, and maintenance | |||
| Filip1l, filamin A-interacting protein 1-like | −1.1 | −1.5 | Regulator of the antiangiogenic activity on endothelial cells |
| Rerg, RAS-like, estrogen-regulated, growth inhibitor | 2.2 | 2.1 | In cell lines, overexpression leads to reduced proliferation rate, colony formation, and tumorigenic potential |
| Genes encoding receptors, channels, and signaling proteins | |||
| Gpr111 | −1.5 | −1.5 | G protein-coupled receptor 111 |
| Lgr6 | 2.1 | 2.0 | Leucine-rich repeat-containing G protein-coupled receptor 6 |
| Mrgprf | −1.5 | −1.7 | MAS-related GPR, member F |
| Tmc7 | 1.7 | 1.5 | Transmembrane channel-like gene family 7 |
| Genes encoding enzymes | |||
| Mboat2 | −1.9 | −1.8 | Membrane bound O-acyltransferase domain containing 2 |
| Gdpd3 | −33.5 | −35.9 | Glycerophosphodiester phosphodiesterase domain containing 3 |
| Glo1 | −1.6 | −1.6 | Glyoxalase 1 |
| Hgsnat | −1.4 | −1.5 | Heparan-α-glucosaminide N-acetyltransferase |
| Hnmt | −2.4 | −2.5 | Histamine N-methyltransferase |
| Mut | −1.6 | −1.7 | Methylmalonyl-coenzyme A mutase |
| Pm20d1 | −1.6 | −1.8 | Peptidase M20 domain containing 1 |
| Vma21, VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | −1.2 | −1.5 | |
| Genes encoding other proteins | |||
| Ctse, cathepsin E | 1.9 | 1.6 | |
| Fbxo44, F-box protein 44 | −3.4 | −3.1 | |
| Park2, Parkinson disease (autosomal recessive, juvenile) 2 | −1.6 | −2.1 | Parkinson disease (autosomal recessive, juvenile) 2 |
| Pkd2l2, polycystic kidney disease 2-like 2 | −1.4 | −1.5 | |
| Rsph3a, radial spoke 3A homolog (Chlamydomonas) | 1.6 | 1.9 | |
| Zfp738/945, zinc finger proteins | −1.5 | −1.7 | |
Bold values are significantly affected by VA status in the left ventricle. Values in unbolded font failed 1 of 3 tests for significance.
*
Cd24a had an FDR = 0.67 and P < 0.040 for LRVAS and P < 0.007 for LRVAD.
†
Cd38 had an FDR = 0.59 and P < 0.003 for LRVAD.
‡
Mki67 had an FDR = 0.67 and P < 0.032 for LRVAD.