Fig. 8.
Proposed mechanism by which ischemia and ischemic preconditioning affect KATP channel subcellular trafficking. Our data indicate that KATP channels are internalized during ischemia by dynamin-dependent endocytosis and that this process depends on CaMKII signaling. IPC and adenosine may stimulate recycling of the internalized KATP channels back to the sarcolemma, and PKC signaling appears to be involved at this step. The larger surface density of KATP channels may promote cardioprotection against further ischemic episodes.