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. 2016 Apr 22;310(11):H1583–H1591. doi: 10.1152/ajpheart.00875.2015

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Fig. 3. — β₂-Spectrin protein levels are reduced in human heart failure samples. A and B: β₂-spectrin protein expression was significantly decreased in LV samples from human nonischemic heart failure (NIHF) compared with nonfailing (NF) human LV heart samples (n = 5 NF, n = 5 NIHF; *P < 0.05). C–J: cardiac protein expression in human NIHF. In line with prior studies, compared with LV samples from NF hearts, LV samples from patients with documented NIHF displayed a significant reduction in ankyrin-B protein expression while showing a significant increase in Ca²⁺/calmodulin-dependent protein kinase (CaMK) IIδ pT287 expression (*P < 0.05). K and L: β₂-spectrin protein levels are reduced in human ischemic heart failure (IHF) samples. β₂-Spectrin protein expression was significantly decreased in LV samples from patients with ischemic heart failure compared with NF human LV heart samples (n = 5 NF, n = 5 IHF; *P < 0.05).