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. Author manuscript; available in PMC: 2017 Jul 15.
Published in final edited form as: J Immunol. 2016 Jun 8;197(2):470–479. doi: 10.4049/jimmunol.1502248

Figure 7. Rasgrp1-deficient mice also lacking CD275/ICOSL do not develop PAP and have normal GM-CSF-specific autoantibody levels.

Figure 7

(a) Representative formalin-fixed paraffin-embedded lung sections from control (upper right, n=3), Rasgrp1-deficient (upper left, n=4), CD275-deficient (lower left, n=3), and Rasgrp1−/− CD275−/− (lower right, n=11) mice stained with H&E (scale bars, 50µm). (b) Concentrations of GM-CSF-specific IgG in the serum of aged control, Rasgrp1-deficient, CD275-deficient, and Rasgrp1−/− CD275−/− mice measured by ELISA. Symbols represent the mean concentration for individual mice (**p≤0.005, One way ANOVA with Tukey’s multiple comparison test).