Table 3.
Effect of adipokines on the composite endpoint of CV death, non-procedural MI and stroke by Baseline BMI Categories.
| Baseline BMI Quintiles BMI Range Events/N in subgroup at baseline* |
Q1 | Q2 | Q3 | Q4 | |
|---|---|---|---|---|---|
| 18<=BMI<25 | 25<=BMI<30 | 30<=BMI<35 | 35<=BMI<66 | Interaction | |
| 33/219 | 124/797 | 108/735 | 97/559 | ||
| HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | P | |
| Baseline Log leptin | 0.6 (0.4, 0.8) |
0.9 (0.7, 1.1) |
0.9 (0.7, 1.3) |
1.2 (0.9, 1.8) |
.06 |
| Change from Baseline Log leptin | 0.7 (0.5, 1.0) |
0.8 (0.6, 1.0) |
0.8 (0.6, 1.0) |
0.9 (0.7, 1.1) |
.67 |
| Baseline Log adiponectin | 1.5 (1.0, 2.4) |
1.2 (1.0, 1.6) |
0.9 (0.7, 1.2) |
1.3 (1, 1.7) |
.40 |
| Change from Baseline Log adiponectin | 1.2 (0.7, 2.2) |
0.9 (0.7, 1.1) |
1.2 (0.9, 1.5) |
1.0 (0.8, 1.3) |
.43 |
| Baseline Log MCP-1 | 1.4 (0.9, 2.2) |
1.0 (0.8, 1.2) |
0.9 (0.7, 1.1) |
0.9 (0.7, 1.1) |
.66 |
| Change from Baseline Log MCP-1 | 3.0 (1.5, 6) |
1.2 (0.9, 1.5) |
0.8 (0.6, 1.0) |
1.0 (0.8, 1.4) |
.007 |
| Baseline Log leptin/adiponectin | 0.6 (0.4, 0.9) |
0.8 (0.6, 1.0) |
1.0 (0.8, 1.4) |
0.9 (0.7, 1.2) |
.22 |
| Change from Baseline Log leptin/adiponectin | 0.7 (0.5, 1.1) |
0.9 (0.7, 1.1) |
0.7 (0.6, 0.9) |
0.9 (0.7, 1.2) |
.42 |
| Baseline Log leptin/BMI | 0.7 (0.5, 0.9) |
0.9 (0.7, 1.1) |
1.0 (0.8, 1.3) |
1.2 (0.9, 1.6) |
.14 |
| Change from Baseline Log leptin/BMI | 0.8 (0.6, 1.2) |
0.8 (0.6, 1.0) |
0.8 (0.6, 1.1) |
0.8 (0.6, 1) |
.98 |
| Baseline Log TNF-α | 1.4 (0.8, 2.6) |
1.3 (1.0, 1.6) |
1.1 (0.9, 1.4) |
1.2 (0.9, 1.5) |
.35 |
| Change from Baseline Log TNF-α | 1.3 (0.9, 1.8) |
1.2 (1, 1.5) |
1.0 (0.8, 1.2) |
1.3 (1.1, 1.5) |
.12 |
| Baseline Log CRP | 1.5 (0.9, 2.4) |
1.8 (1.4, 2.2) |
1.6 (1.2, 2) |
1.0 (0.7, 1.3) |
.03 |
| Change from Baseline Log CRP | 0.9 (0.5, 1.5) |
1.5 (1.2, 1.8) |
1.4 (1.1, 1.8) |
1.5 (1.1, 2.0) |
.47 |
| Baseline Log IL-6 | 2.1 (1.3, 3.5) |
1.4 (1.1, 1.8) |
1.1 (0.9, 1.4) |
1.2 (0.9, 1.6) |
.04 |
| Change from Baseline Log IL-6 | 1.1 (0.6, 2) |
1.4 (1.1, 1.7) |
0.9 (0.7, 1.1) |
1.2 (0.9, 1.6) |
.05 |
All models fully adjusted.
*
Eighteen (18) participants without events were missing BMI at baseline, and 2 participants with events were missing BMI at baseline. Thus this table represents 2310 participants and 362 events.