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. Author manuscript; available in PMC: 2017 Jul 5.
Published in final edited form as: Mol Pharm. 2016 Feb 29;13(7):2148–2154. doi: 10.1021/acs.molpharmaceut.5b00905

Figure 5.

Figure 5

(A) SPR sensogram for the association and disassociation of the bare VEGF (black line, 1), the mixture of VEGF and unmodified alginate (blue line, 2), and the complex of VEGF and alginate sulfates (DSsulfates = 13.3%) (red line, 3) to the VEGFR-2 immobilized on the lipid bilayer surface built on a gold chip. (B) Association (ka) and dissociation rates (kd) were quantified by fitting the RU response curve obtained in (A), to the Langmuir adsorption model. The binding affinity constant (KA) between VEGF and the VEGFR-2 was quantified by dividing ka by kd.