Table 2.
Partially adjusted Model 1a
|
Fully adjusted Model 2b
|
HbA1c as a mediator: Model 3c
|
BMI z score as a mediator: Model 4d
|
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βe | SE | Pf | βe | SE | Pf | βe | SE | Pf | βe | SE | Pf | |
Log HbA1c, % | −0.01 | 0.01 | 0.42 | −0.02 | 0.01 | 0.02 | −0.02 | 0.01 | 0.04 | |||
Lipids | ||||||||||||
Total Cholesterol, mg/dL | −3.59 | 1.33 | 0.007 | −4.04 | 1.46 | 0.006 | −3.17 | 1.40 | 0.02 | −3.71 | 1.47 | 0.01 |
LDL Cholesterol, mg/dL | −3.11 | 1.08 | 0.004 | −3.39 | 1.19 | 0.004 | −2.80 | 1.16 | 0.02 | −3.16 | 1.20 | 0.008 |
HDL Cholesterol, mg/dL | −0.26 | 0.46 | 0.58 | −0.18 | 0.51 | 0.73 | −0.02 | 0.50 | 0.97 | −0.04 | 0.50 | 0.94 |
LDL/HDL ratio | −0.05 | 0.03 | 0.03 | −0.07 | 0.03 | 0.02 | −0.06 | 0.03 | 0.03 | −0.07 | 0.03 | 0.01 |
Non-HDL cholesterol, mg/dL | −3.34 | 1.21 | 0.006 | −3.86 | 1.32 | 0.004 | −3.15 | 1.28 | 0.01 | −3.67 | 1.33 | 0.006 |
Log triglycerides, mg/dL | −0.01 | 0.02 | 0.68 | −0.02 | 0.02 | 0.34 | −0.01 | 0.02 | 0.54 | −0.02 | 0.02 | 0.27 |
Apolipoprotein B, mg/dL | −1.22 | 1.01 | 0.23 | −0.82 | 1.08 | 0.45 | −0.60 | 1.01 | 0.55 | −0.54 | 1.09 | 0.62 |
BPg | ||||||||||||
Systolic BP, mm Hg | ||||||||||||
P for interaction | 0.04 | 0.03 | 0.03 | 0.02 | ||||||||
Non-Hispanic white | 0.98 | 0.44 | 0.03 | 1.21 | 0.46 | 0.009 | 1.25 | 0.47 | 0.008 | 1.18 | 0.45 | 0.009 |
Other | −0.91 | 0.81 | 0.26 | −0.83 | 0.87 | 0.34 | −0.90 | 0.88 | 0.30 | −1.07 | 0.85 | 0.21 |
Diastolic BP, mm Hg | 0.14 | 0.37 | 0.72 | 0.57 | 0.40 | 0.16 | 0.59 | 0.42 | 0.16 | 0.53 | 0.40 | 0.19 |
Obesity | ||||||||||||
BMI z score | 0.02 | 0.04 | 0.56 | 0.05 | 0.04 | 0.22 | 0.06 | 0.04 | 0.19 | |||
Waist circumference, cm | −0.10 | 0.43 | 0.83 | 0.20 | 0.46 | 0.67 | 0.33 | 0.48 | 0.50 |
Abbreviations: BMI, body mass index; BP, blood pressure; HbA1c, hemoglobin A1c; HDL, high-density lipoprotein; LDL, low-density lipoprotein; SE, standard error.
Model 1 adjusted for age, sex, race, diabetes duration, parental education, family income, parental history of diabetes, clinical site.
Model 2, model 1 + physical activity, sedentary behavior, smoking, total calories, insulin regimen, daily insulin dose per kilogram.
Model 3, model 2 + HbA1c.
Model 4, model 2 + BMI z score.
β for 2 points increment in mKIDMED score.
P value of 0.05 or less was highlighted in bold.
Height was additionally adjusted for BP.