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. Author manuscript; available in PMC: 2017 Jul 15.
Published in final edited form as: J Immunol. 2016 Jun 13;197(2):458–469. doi: 10.4049/jimmunol.1502283

Figure 1. Pbx1-d overexpression in CD4+ T cells reproduced the phenotypes of B6.Sle1a1 mice.

Figure 1

A. Representative serum ANA staining patterns in B6, Pbx1-d Tg− (Tg−), B6.Sle1, B6.Sle1a1, Pbx1-d Tg (Tg+), and TC mice as positive control. The pattern distribution (nuclear, cytoplasmic or negative) was significantly different between Pbx1-d Tg+ or B6.Sle1a1 and (B6 + Tg−) combined mice (n = 10–18 per strain). Serum anti-dsDNA (B) and anti-chromatin (C) IgG (n = 10–15). D. TN/TEM ratio in the spleen and mLN from B6 and Pbx1-d Tg mice (n = 3–4). Mice were 7–12 month old for A–D. E. Maximum weekly percentage of body weight loss by B6.Rag1−/ − mice up to 8 weeks after transfer of Pbx1-d Tg or B6 TEff cells. F. Colitis pathology score 8 weeks after transfer with representative images of colon histology taken with the same 40X magnification shown on the right. Each symbol represents a mouse. *P < 0.05, **P < 0.01.