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COMT inhibition reverses novel object recognition deficit in COMT-Val transgenic mice. (a) Tolcapone administration produced a significant difference in exploration time between the novel and familiar objects. (b) Tolcapone (30 mg/kg) significantly improved the novel object recognition index compared to vehicle administration in COMT-Val transgenic mice. All data presented as mean ± SEM. n = 6/group; * p < 0.05.
