Table 1.
Overall experimental procedure and treatment groups. IVSA: intravenous self-administration. PavCA: Pavlovian conditioned approach. CRf: conditioned reinforcement. FR: fixed ratio. Note that for Experiments 2 and 3, separate paired and unpaired groups received these treatments.
| Table 1A | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PavCA | IVSA | |||||||||
| Experiment 1: Nicotine IVSA | Food-Cup Training | PavCA | Surgery/Recovery | Aquisition | Cue Removal | FR Escalation | Extinction | Reinstatement | ||
| 1 day | 5 days | 5 days | FR1 (10 days) | FR1 (2 days) | FR1 (5 days) | FR2 (2 days) | FR5 (10 days) | 8 days | 1 day | |
| Table 1B | |||||
|---|---|---|---|---|---|
| Food-Cup Training 1 day | Habituation 1 day | PavCA 5 days | Habituation 1 day | CRf 1 day | |
| Experiment 2: Nicotine PavCA | No injections | Saline | Saline | Saline | Saline |
| Nicotine | Nicotine | ||||
| Nicotine | Nicotine | Saline | Saline | ||
| Nicotine | Nicotine | ||||
| Experiment 3: Ethanol PavCA | No injections | Saline | Saline | Saline | Saline |
| Ethanol | Ethanol | ||||
| Ethanol | Ethanol | Saline | Saline | ||
| Ethanol | Ethanol | ||||